A multi-agent AI system (MAS) is composed of multiple autonomous agents that interact, exchange information, and make decisions based on internal generative models. Recent advances in large language models and tool-using agents have made MAS increasingly practical in areas like scientific discovery and collaborative automation. However, key questions remain: When are MAS more effective than single-agent systems? What new safety risks arise from agent interactions? And how should we evaluate their reliability and structure? This paper outlines a formal framework for analyzing MAS, focusing on two core aspects: effectiveness and safety. We explore whether MAS truly improve robustness, adaptability, and performance, or merely repackage known techniques like ensemble learning. We also study how inter-agent dynamics may amplify or suppress system vulnerabilities. While MAS are relatively new to the signal processing community, we envision them as a powerful abstraction that extends classical tools like distributed estimation and sensor fusion to higher-level, policy-driven inference. Through experiments on data science automation, we highlight the potential of MAS to reshape how signal processing systems are designed and trusted.

Multi-agent artificial intelligence systems are increasingly deployed in clinical settings, yet the relationship between component-level optimization and system-wide performance remains poorly understood. We evaluated this relationship using 2,400 real patient cases from the MIMIC-CDM dataset across four abdominal pathologies (appendicitis, pancreatitis, cholecystitis, diverticulitis), decomposing clinical diagnosis into information gathering, interpretation, and differential diagnosis. We evaluated single agent systems (one model performing all tasks) against multi-agent systems (specialized models for each task) using comprehensive metrics spanning diagnostic outcomes, process adherence, and cost efficiency. Our results reveal a paradox: while multi-agent systems generally outperformed single agents, the component-optimized or Best of Breed system with superior components and excellent process metrics (85.5% information accuracy) significantly underperformed in diagnostic accuracy (67.7% vs. 77.4% for a top multi-agent system). This finding underscores that successful integration of AI in healthcare requires not just component level optimization but also attention to information flow and compatibility between agents. Our findings highlight the need for end to end system validation rather than relying on component metrics alone.

Recently, with the development of tool-calling capabilities in large language models (LLMs), these models have demonstrated significant potential for automating electronic design automation (EDA) flows by interacting with EDA tool APIs via EDA scripts. However, considering the limited understanding of EDA tools, LLMs face challenges in practical scenarios where diverse interfaces of EDA tools exist across different platforms. Additionally, EDA flow automation often involves intricate, long-chain tool-calling processes, increasing the likelihood of errors in intermediate steps. Any errors will lead to the instability and failure of EDA flow automation. To address these challenges, we introduce EDAid, a multi-agent collaboration system where multiple agents harboring divergent thoughts converge towards a common goal, ensuring reliable and successful EDA flow automation. Specifically, each agent is controlled by ChipLlama models, which are expert LLMs fine-tuned for EDA flow automation. Our experiments demonstrate the state-of-the-art (SOTA) performance of our ChipLlama models and validate the effectiveness of our EDAid in the automation of complex EDA flows, showcasing superior performance compared to single-agent systems.

Multi-Agent Large Language Models (LLMs) are gaining significant attention for their ability to harness collective intelligence in complex problem-solving, decision-making, and planning tasks. This aligns with the concept of the wisdom of crowds, where diverse agents contribute collectively to generating effective solutions, making it particularly suitable for educational settings. Senior design projects, also known as capstone or final year projects, are pivotal in engineering education as they integrate theoretical knowledge with practical application, fostering critical thinking, teamwork, and real-world problem-solving skills. In this paper, we explore the use of Multi-Agent LLMs in supporting these senior design projects undertaken by engineering students, which often involve multidisciplinary considerations and conflicting objectives, such as optimizing technical performance while addressing ethical, social, and environmental concerns. We propose a framework where distinct LLM agents represent different expert perspectives, such as problem formulation agents, system complexity agents, societal and ethical agents, or project managers, thus facilitating a holistic problem-solving approach. This implementation leverages standard multi-agent system (MAS) concepts such as coordination, cooperation, and negotiation, incorporating prompt engineering to develop diverse personas for each agent. These agents engage in rich, collaborative dialogues to simulate human engineering teams, guided by principles from swarm AI to efficiently balance individual contributions towards a unified solution. We adapt these techniques to create a collaboration structure for LLM agents, encouraging interdisciplinary reasoning and negotiation similar to real-world senior design projects. To assess the efficacy of this framework, we collected six proposals of engineering and computer science of...

Emergency department (ED) overcrowding and the complexity of rapid decision-making in critical care settings pose significant challenges to healthcare systems worldwide. While clinical decision support systems (CDSS) have shown promise, the integration of large language models (LLMs) offers new possibilities for enhancing triage accuracy and clinical decision-making. This study presents an LLM-driven CDSS designed to assist ED physicians and nurses in patient triage, treatment planning, and overall emergency care management. We developed a multi-agent CDSS utilizing Llama-3-70b as the base LLM, orchestrated by CrewAI and Langchain. The system comprises four AI agents emulating key ED roles: Triage Nurse, Emergency Physician, Pharmacist, and ED Coordinator. It incorporates the Korean Triage and Acuity Scale (KTAS) for triage assessment and integrates with the RxNorm API for medication management. The model was evaluated using the Asclepius dataset, with performance assessed by a clinical emergency medicine specialist. The CDSS demonstrated high accuracy in triage decision-making compared to the baseline of a single-agent system. Furthermore, the system exhibited strong performance in critical areas, including primary diagnosis, critical findings identification, disposition decision-making, treatment planning, and resource allocation. Our multi-agent CDSS demonstrates significant potential for supporting comprehensive emergency care management. By leveraging state-of-the-art AI technologies, this system offers a scalable and adaptable tool that could enhance emergency medical care delivery, potentially alleviating ED overcrowding and improving patient outcomes. This work contributes to the growing field of AI applications in emergency medicine and offers a promising direction for future research and clinical implementation.

The structure of the book makes examples and applications, and a section such as the agent's ability to it useful for practitioners from AI and dedicated to the relationship between perceive the environment and maintain general computer science as well as multiagent systems and various knowledge about it, reason about other areas such as aviation, transportation, other research areas. This book compiles said environment, and execute particular and business. The book presents the important concepts and actions to solve tasks. The design the basics of all the components methodologies required to develop a of a single-agent system, although not required to build a multiagent system.